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Article

OX-22high CD4+ T cells induce wasting disease with multiple organ pathology: prevention by the OX-22low subset.

The Journal of experimental medicine - 1 Dec 1990

Powrie F, Mason D

Abstract excerpt

Congenitally athymic rats injected with CD45RBhigh CD4+ T cells from congenic euthymic donors developed a severe wasting disease with inflammatory infiltrates in liver, lung, stomach, thyroid, and pancreas. In contrast, recipients of CD45RBlow CD4+ T cells remained well and continued to gain weight. Animals given unfractionated CD4+ T cells, i.e., a mixture of approximately two-thirds CD45RBhigh and one-third...

Topics

Animals
Antibodies, Monoclonal
CD4 Antigens
Graft vs Host Disease
Lung
Phenotype
Rats
Rats, Mutant Strains
Rats, Nude
Reference Values
T-Lymphocyte Subsets
T-Lymphocytes

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Identifiers

PMID: 2258700
DOI: 10.1084/jem.172.6.1701
PMCID: PMC2188779

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2258700-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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