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Article

Genetic dissection of lymphopenia from autoimmunity by introgression of mutated Ian5 gene onto the F344 rat.

Journal of autoimmunity - 1 Dec 2003

Moralejo Daniel H, Park Hyunhee A, Speros Sara J, MacMurray Armand J, Kwitek Anne E, Jacob Howard J, Lander Eric S, Lernmark Ake

Abstract excerpt

Peripheral T cell lymphopenia (lyp) in the BioBreeding (BB) rat is linked to a frameshift mutation in Ian5, a member of the Immune Associated Nucleotide (Ian) gene family on rat chromosome 4. This lymphopenia leads to type 1 (insulin-dependent) diabetes mellitus (T1DM) at rates up to 100% when combined with the BB rat MHC RT1 u/u genotype. In order, to better study the lymphopenia phenotype without possible...

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Identifiers

PMID: 14624755
DOI: 10.1016/s0896-8411(03)00138-0
PMCID: PMC7126882

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic dissection of lymphopenia from autoimmunity by introgression of mutated Ian5 gene onto the F344 rat.PMID 14624755Read ↗

Transgenic rescue demonstrates involvement of the Ian5 gene in T cell development in the rat.Semantic proximity Read ↗

Sequence variation and expression of the Gimap gene family in the BB rat.Semantic proximity Read ↗

Diabetes-prone and diabetes-resistant BB rats share a common major diabetes susceptibility locus, iddm4: additional evidence for a "universal autoimmunity locus" on rat chromosome 4.Semantic proximity Read ↗

The diabetes-prone BB rat carries a frameshift mutation in Ian4, a positional candidate of Iddm1.Semantic proximity Read ↗

BB rat <i>lyp</i> mutation and Type 1 diabetesSemantic proximity Read ↗

Haplotype tag single nucleotide polymorphism analysis of the human orthologues of the rat type 1 diabetes genes Ian4 (Lyp/Iddm1) and Cblb.Semantic proximity Read ↗

Impaired post-thymic development of regulatory CD4+25+ T cells contributes to diabetes pathogenesis in BB rats.Semantic proximity Read ↗

BB rat diabetes susceptibility and body weight regulation genes colocalize on chromosome 2.Semantic proximity Read ↗

A novel susceptibility locus on rat chromosome 8 affects spontaneous but not experimentally induced type 1 diabetes.Semantic proximity Read ↗

Polygenic nature of spontaneous diabetes in the rat. Permissive MHC haplotype and presence of the lymphopenic trait of the BB rat are not sufficient to produce susceptibility.Semantic proximity Read ↗

Involvement of eotaxin, eosinophils, and pancreatic predisposition in development of type 1 diabetes mellitus in the BioBreeding rat.Semantic proximity Read ↗

The lymphopenia mutation of the BB rat causes inappropriate apoptosis of mature thymocytes.Semantic proximity Read ↗

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