Article
Phagocytosis is the main CR3-mediated function affected by the lupus-associated variant of CD11b in human myeloid cells.
PloS one - 1 Jan 2013
Fossati-Jimack Liliane, Ling Guang Sheng, Cortini Andrea, Szajna Marta, Malik Talat H, McDonald Jacqueline U, Pickering Matthew C, Cook H Terence, Taylor Philip R, Botto Marina
Abstract excerpt
The CD11b/CD18 integrin (complement receptor 3, CR3) is a surface receptor on monocytes, neutrophils, macrophages and dendritic cells that plays a crucial role in several immunological processes including leukocyte extravasation and phagocytosis. The minor allele of a non-synonymous CR3 polymorphism (rs1143679, conversation of arginine to histidine at position 77: R77H) represents one of the strongest genetic...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.