Article
The role of Ia in the formation of a T cell antigen-recognition complex.
Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 1990
Esch T R, McKean D J, Thomas D W
Abstract excerpt
We have evaluated the ability of a peptide-specific, I-Ak-restricted murine T hybridoma to bind its Ag in the presence and absence of class II MHC molecules. The restricting Ia molecule, when supplied as a plasma membrane preparation of I-Ak-expressing APC, specifically increases the avidity of t...
Topics
- Amino Acid Sequence
- Animals
- Antigen-Presenting Cells
- Cell Line
- Cell Membrane
- Fibrinopeptide B
- Histocompatibility Antigens Class II
- In Vitro Techniques
- Macromolecular Substances
- Mice
- Molecular Sequence Data
- Mutation
- Protein Binding
- Receptors, Antigen, T-Cell
- Structure-Activity Relationship
- T-Lymphocytes