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Article

The role of Ia in the formation of a T cell antigen-recognition complex.

Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 1990

Esch T R, McKean D J, Thomas D W

Abstract excerpt

We have evaluated the ability of a peptide-specific, I-Ak-restricted murine T hybridoma to bind its Ag in the presence and absence of class II MHC molecules. The restricting Ia molecule, when supplied as a plasma membrane preparation of I-Ak-expressing APC, specifically increases the avidity of the Ag-binding complex by lengthening its t1/2, without affecting the rate at which the complex is formed. Experiments...

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PMID: 2258604

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APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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