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The Intermediate Region of Helicobacter pylori VacA Is a Determinant of Toxin Potency in a Jurkat T Cell Assay

15 May 2012

Abstract excerpt

Colonization of the human stomach with Helicobacter pylori is a risk factor for peptic ulceration, noncardia gastric adenocarcinoma, and gastric lymphoma. The secreted VacA toxin is an important H. pylori virulence factor that causes multiple alterations in gastric epithelial cells and T cells. Several families of vacA alleles have been described, and H. pylori strains containing certain vacA types (s1, i1, and...

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PMID: 22585965
DOI: 10.1128/iai.00052-12

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Intermediate Region of Helicobacter pylori VacA Is a Determinant of Toxin Potency in a Jurkat T Cell AssayPMID 22585965Read ↗

A new Helicobacter pylori vacuolating cytotoxin determinant, the intermediate region, is associated with gastric cancer.Semantic proximity Read ↗

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A Role for the Vacuolating Cytotoxin, VacA, in Colonization and Helicobacter pylori–Induced Metaplasia in the StomachSemantic proximity Read ↗

Relationship of <i>vacA</i> Genotypes of <i>Helicobacter pylori</i> to <i>cagA</i> Status, Cytotoxin Production, and Clinical OutcomeSemantic proximity Read ↗

The cell-specific phenotype of the polymorphic vacA midregion is independent of the appearance of the cell surface receptor protein tyrosine phosphatase beta.Semantic proximity Read ↗

Role of deletion located between the intermediate and middle regions of the Helicobacter pylori vacA gene in cases of gastroduodenal diseases.Semantic proximity Read ↗

Helicobacter pylori Vacuolating Toxin and Gastric Cancer.Semantic proximity Read ↗

The m2 form of the Helicobacter pylori cytotoxin has cell type-specific vacuolating activity.Semantic proximity Read ↗

Remodeling the host environment: modulation of the gastric epithelium by the Helicobacter pylori vacuolating toxin (VacA)Semantic proximity Read ↗

Clinical and pathological importance of heterogeneity in vacA, the vacuolating cytotoxin gene of Helicobacter pylori.Semantic proximity Read ↗

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