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Article

A new Helicobacter pylori vacuolating cytotoxin determinant, the intermediate region, is associated with gastric cancer.

Gastroenterology - 1 Sept 2007

Rhead Joanne L, Letley Darren P, Mohammadi Marjan, Hussein Nawfal, Mohagheghi Mohammad A, Eshagh Hosseini Mahmoud, Atherton John C

Abstract excerpt

BACKGROUND & AIMS: Helicobacter pylori is the main cause of peptic ulceration and gastric adenocarcinoma. The vacuolating cytotoxin gene, vacA, is a major determinant of virulence. Two naturally polymorphic sites in vacA, the signal region and midregion, are well-characterized determinants of tox...

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Identifiers

PMID: 17854597
DOI: 10.1053/j.gastro.2007.06.056

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17854597-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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