Article
The m2 form of the Helicobacter pylori cytotoxin has cell type-specific vacuolating activity.
Proceedings of the National Academy of Sciences of the United States of America - 18 Aug 1998
Pagliaccia C, de Bernard M, Lupetti P, Ji X, Burroni D, Cover T L, Papini E, Rappuoli R, Telford J L, Reyrat J M
Abstract excerpt
The Helicobacter pylori toxin VacA causes vacuolar degeneration in mammalian cell lines in vitro and plays a key role in peptic ulcer disease. Two alleles, m1 and m2, of the mid-region of the vacA gene have been described, and the m2 cytotoxin always has been described as inactive in the in vitro HeLa cell assay. However, the m2 allele is associated with peptic ulcer and is prevalent in populations in which...
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