Article
The m2 form of the Helicobacter pylori cytotoxin has cell type-specific vacuolating activity.
Proceedings of the National Academy of Sciences of the United States of America - 18 Aug 1998
Pagliaccia C, de Bernard M, Lupetti P, Ji X, Burroni D, Cover T L, Papini E, Rappuoli R, Telford J L, Reyrat J M
Abstract excerpt
The Helicobacter pylori toxin VacA causes vacuolar degeneration in mammalian cell lines in vitro and plays a key role in peptic ulcer disease. Two alleles, m1 and m2, of the mid-region of the vacA gene have been described, and the m2 cytotoxin always has been described as inactive in the in vitro...
Topics
- Alleles
- Bacterial Proteins
- Bacterial Toxins
- Base Sequence
- Cytotoxins
- DNA Primers
- DNA, Bacterial
- Genes, Bacterial
- HeLa Cells
- Helicobacter pylori
- Humans
- Peptic Ulcer
- Polymerase Chain Reaction
- Stomach Neoplasms