Article
Clinical and pathological importance of heterogeneity in vacA, the vacuolating cytotoxin gene of Helicobacter pylori.
Gastroenterology - 1 Jan 1997
Atherton J C, Peek R M, Tham K T, Cover T L, Blaser M J
Abstract excerpt
BACKGROUND & AIMS: vacA encodes the vacuolating cytotoxin of Helicobacter pylori and exhibits marked variation in signal sequence and midgene coding regions. The implications for gastroduodenal pathology are unknown. The aim of this study was to define the association of vacA genotype with gastri...
Topics
- Adult
- Aged
- Aged, 80 and over
- Anti-Inflammatory Agents, Non-Steroidal
- Aspirin
- Atrophy
- Bacterial Proteins
- Cytotoxins
- Duodenal Ulcer
- Gastric Mucosa
- Genes, Bacterial
- Genotype
- Helicobacter pylori
- Humans
- Immunity, Cellular
- Lymphocytes
- Middle Aged
- Neutrophils