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Article

Functional Properties of Helicobacter pylori VacA Toxin m1 and m2 Variants.

Infection and immunity - 20 May 2020

Caston Rhonda R, Sierra Johanna C, Foegeding Nora J, Truelock Mandy D, Campbell Anne M, Frick-Cheng Arwen E, Bimczok Diane, Wilson Keith T, McClain Mark S, Cover Timothy L

Abstract excerpt

Helicobacter pylori colonizes the gastric mucosa and secretes a pore-forming toxin (VacA). Two main types of VacA, m1 and m2, can be distinguished by phylogenetic analysis. Type m1 forms of VacA have been extensively studied, but there has been relatively little study of m2 forms. In this study, we generated H. pylori strains producing chimeric proteins in which VacA m1 segments of a parental strain were replaced...

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Identifiers

PMID: 32284370
DOI: 10.1128/IAI.00032-20
PMCID: PMC7240096

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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