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Article

Role of deletion located between the intermediate and middle regions of the Helicobacter pylori vacA gene in cases of gastroduodenal diseases.

Journal of clinical microbiology - 1 Nov 2009

Ogiwara Hiroaki, Sugimoto Mitsushige, Ohno Tomoyuki, Vilaichone Ratha-Korn, Mahachai Varocha, Graham David Y, Yamaoka Yoshio

Abstract excerpt

The vacuolating cytotoxin gene of Helicobacter pylori, vacA, induces cytoplasmic vacuolation in gastric epithelial cells. Recently, the vacA intermediate (i) region, which is located between the signal (s) and middle (m) regions, was identified as a third polymorphic determinant of vacA activity. In vacA, there are approximately 81-bp deletions between the vacA i and m regions (denoted the d region). The aim was...

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Identifiers

PMID: 19726606
DOI: 10.1128/JCM.00887-09
PMCID: PMC2772588

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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