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Article

Determinants of Non-toxicity in the Gastric Pathogen Helicobacter pylori

1 Jul 2003

Abstract excerpt

The Helicobacter pylori vacuolating cytotoxin gene, vacA, is naturally polymorphic, the two most diverse regions being the signal region (which can be type s1 or s2) and the mid region (m1 or m2). Previous work has shown which features of vacA make peptic ulcer and gastric cancer-associated type s1/m1 and s1/m2 strains toxic. vacA s2/m2 strains are associated with lower peptic ulcer and gastric cancer risk and...

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PMID: 12738773
DOI: 10.1074/jbc.m304071200

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