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<i>Ebolavirus</i> VP35 uses a bimodal strategy to bind dsRNA for innate immune suppression

14 Dec 2009

Abstract excerpt

Ebolavirus causes a severe hemorrhagic fever and is divided into five distinct species, of which Reston ebolavirus is uniquely nonpathogenic to humans. Disease caused by ebolavirus is marked by early immunosuppression of innate immune signaling events, involving silencing and sequestration of double-stranded RNA (dsRNA) by the viral protein VP35. Here we present unbound and dsRNA-bound crystal structures of the...

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PMID: 20018665
DOI: 10.1073/pnas.0910547107

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