Article

Defining the Immunomodulatory Determinants of 3-mer Oligonucleotides on TLR7 and TLR8 sensing

2026-04-29

Abstract excerpt

Chemical modifications such as 2′-O-methyl (2′-OMe) are central to the efficacy and tolerability of RNA therapeutics. We recently identified that 2′-OMe RNA fragments as short as three nucleotides can exert opposing effects on Toll-like receptor 8 (TLR8) sensing in a motif-dependent manner. This discovery raises important considerations for degradation products of chemically modified RNA therapeutics, which may ge...

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Literature Corpus work: 08451d60-a8aa-52ed-bf21-4e640eb8d009
DOI: 10.64898/2026.04.29.720527

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