Article

2’-O-Methyl-guanosine 3-base RNA fragments mediate essential natural TLR7/8 antagonism

2024-07-25

Abstract excerpt

Recognition of RNA fragments by Toll-like receptors (TLR) 7 and 8 is a key contributor to the initiation of a protective innate immune response against pathogens. A long-standing enigma is how degradation products of host RNAs, generated by the daily phagocytic clearance of billions of apoptotic cells, fail to activate TLR7 and TLR8 signalling 1 . Here, we report that select 2’-O-methyl (2’-Ome) guanosine RNA fra...

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Literature Corpus work: b322f673-5a6e-5882-891b-b14a7e096536
DOI: 10.1101/2024.07.25.605091

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