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Article

Dimerization of Toll-like receptor 3 (TLR3) is required for ligand binding.

The Journal of biological chemistry - 19 Nov 2010

Wang Yan, Liu Lin, Davies David R, Segal David M

Abstract excerpt

TLR3 (Toll-like receptor 3) recognizes dsRNA, a potent indicator of viral infection. The extracellular domain of TLR3 dimerizes when it binds dsRNA, and the crystal structure of the dimeric complex reveals three sites of interaction on each extracellular domain, two that bind dsRNA and one that is responsible for dimer formation. The goal of this study was to determine which amino acid residues are essential for...

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Source

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Identifiers

PMID: 20861016
DOI: 10.1074/jbc.M110.167973
PMCID: PMC2978612

Genes

TLR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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