Article

Covalent Modulators of Immune Regulatory Transcription Factors IRF8 and IRF5

2025-08-03

Abstract excerpt

Transcription factors are among the most challenging targets for drug discovery due to their lack of classical binding pockets and high degree of intrinsic disorder, despite the therapeutic importance of many of these proteins. IRF5 and IRF8 are key transcriptional regulators of innate immune signaling that orchestrate pro-inflammatory gene expression programs in response to stimuli such as toll-like receptor acti...

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Literature Corpus work: aafe1c58-ad33-568e-8b22-cc4741e38504
DOI: 10.1101/2025.08.03.668300

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