Article
The human gastric cancer-associated DNA polymerase β variant D160N is a mutator that induces cellular transformation.
DNA repair - 1 Apr 2012
Donigan Katherine A, Hile Suzanne E, Eckert Kristin A, Sweasy Joann B
Abstract excerpt
Approximately 30% of human tumors sequenced to date harbor mutations in the POLB gene that are not present in matched normal tissue. Many mutations give rise to enzymes that contain non-synonymous single amino acid substitutions, several of which have been found to have aberrant activity or fidelity and transform cells when expressed. The DNA Polymerase β (Pol β) variant Asp160Asn (D160N) was first identified in...
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