Article
The pulmonary fibrosis-associated MUC5B promoter polymorphism does not influence the development of interstitial pneumonia in systemic sclerosis.
Chest - 1 Dec 2012
Peljto Anna L, Steele Mark P, Fingerlin Tasha E, Hinchcliff Monique E, Murphy Elissa, Podlusky Sofia, Carns Mary, Schwarz Marvin, Varga John, Schwartz David A
Abstract excerpt
BACKGROUND: More than 80% of patients with systemic sclerosis (SSc) develop lung involvement, most commonly interstitial pneumonia (IP). We recently identified a common variant in the promoter region of MUC5B (rs35705950) that has a significant effect on the risk of developing both familial and sporadic forms of IP. We hypothesized that this MUC5B promoter polymorphism is also associated with IP in subjects with...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.