Article
Mucin 5B promoter polymorphism is associated with idiopathic pulmonary fibrosis but not with development of lung fibrosis in systemic sclerosis or sarcoidosis.
Thorax - 1 May 2013
Stock Carmel J, Sato Hiroe, Fonseca Carmen, Banya Winston A S, Molyneaux Philip L, Adamali Huzaifa, Russell Anne-Marie, Denton Christopher P, Abraham David J, Hansell David M, Nicholson Andrew G, Maher Toby M, Wells Athol U, Lindahl Gisela E, Renzoni Elisabetta A
Abstract excerpt
BACKGROUND: A polymorphism (rs35705950) 3 kb upstream of MUC5B, the gene encoding Mucin 5 subtype B, has been shown to be associated with familial and sporadic idiopathic pulmonary fibrosis (IPF). We set out to verify whether this variant is also a risk factor for fibrotic lung disease in other settings and to confirm the published findings in a UK Caucasian IPF population. METHODS: Caucasian UK healthy controls...
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