FAM13A polymorphism is associated with a usual interstitial pneumonia pattern in patients with systemic sclerosis-associated interstitial lung disease.

doi:10.1093/rheumatology/keae573

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

FAM13A polymorphism is associated with a usual interstitial pneumonia pattern in patients with systemic sclerosis-associated interstitial lung disease.

Rheumatology (Oxford, England) - 1 Dec 2025

Bernstein Elana J, Boin Francesco, Elicker Brett, Luo Yiming, Ren Yawen, Zhang Meng, Varga John, Assassi Shervin

Abstract excerpt

OBJECTIVES: The MUC5B promoter single nucleotide polymorphism (SNP) rs35705950 has been associated with idiopathic pulmonary fibrosis (IPF) and RA-related interstitial lung disease (ILD), but not with SSc-ILD. We hypothesized that the MUC5B promoter polymorphism or other IPF susceptibility loci are associated with an increased risk for the uncommon SSc-usual interstitial pneumonia (UIP) endophenotype, rather than...

Read the complete abstract on PubMed

Topics

Humans
Female
Male
Lung Diseases, Interstitial

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Scleroderma, Systemic

Mucin-5B

Middle Aged

Polymorphism, Single Nucleotide

Cross-Sectional Studies

Aged

Genetic Predisposition to Disease

GTPase-Activating Proteins

Tomography, X-Ray Computed

Idiopathic Pulmonary Fibrosis

Promoter Regions, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 39418199
DOI: 10.1093/rheumatology/keae573
PMCID: PMC12695041

Genes

MUC5B
FAM13A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 22 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

FAM13A polymorphism is associated with a usual interstitial pneumonia pattern in patients with systemic sclerosis-associated interstitial lung disease.PMID 39418199Read ↗

The pulmonary fibrosis-associated MUC5B promoter polymorphism does not influence the development of interstitial pneumonia in systemic sclerosis.Semantic proximity Read ↗

Genetic susceptibility loci of idiopathic interstitial pneumonia do not represent risk for systemic sclerosis: a case control study in Caucasian patients.Semantic proximity Read ↗

Assessing the MUC5B promoter variant in a large cohort of systemic sclerosis-associated interstitial lung disease.Semantic proximity Read ↗

Mucin 5B promoter polymorphism is associated with idiopathic pulmonary fibrosis but not with development of lung fibrosis in systemic sclerosis or sarcoidosis.Semantic proximity Read ↗

The MUC5B variant is associated with idiopathic pulmonary fibrosis but not with systemic sclerosis interstitial lung disease in the European Caucasian population.Semantic proximity Read ↗

CT scan findings of probable usual interstitial pneumonitis have a high predictive value for histologic usual interstitial pneumonitis.Semantic proximity Read ↗

Association of rare single-nucleotide variant MUC5B rs35705950 with interstitial lung disease in Japanese rheumatoid arthritis.Semantic proximity Read ↗

The MUC5B promoter polymorphism is associated with specific interstitial lung abnormality subtypes.Semantic proximity Read ↗

Etiology, Risk Factors, and Biomarkers in Systemic Sclerosis with Interstitial Lung Disease.Semantic proximity Read ↗

Exploration of the MUC5B promoter variant and ILD risk in patients with autoimmune myositis.Semantic proximity Read ↗

CT Imaging Phenotypes of Pulmonary Fibrosis in the MUC5B Promoter Site Polymorphism.Semantic proximity Read ↗

Defining genetic risk factors for scleroderma-associated interstitial lung disease : IRF5 and STAT4 gene variants are associated with scleroderma while STAT4 is protective against scleroderma-associated interstitial lung disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.