Article
A common MUC5B promoter polymorphism and pulmonary fibrosis.
The New England journal of medicine - 21 Apr 2011
Seibold Max A, Wise Anastasia L, Speer Marcy C, Steele Mark P, Brown Kevin K, Loyd James E, Fingerlin Tasha E, Zhang Weiming, Gudmundsson Gunnar, Groshong Steve D, Evans Christopher M, Garantziotis Stavros, Adler Kenneth B, Dickey Burton F, du Bois Roland M, Yang Ivana V, Herron Aretha, Kervitsky Dolly, Talbert Janet L, Markin Cheryl, Park Joungjoa, Crews Anne L, Slifer Susan H, Auerbach Scott, Roy Michelle G, Lin Jia, Hennessy Corinne E, Schwarz Marvin I, Schwartz David A
Abstract excerpt
BACKGROUND: The mutations that have been implicated in pulmonary fibrosis account for only a small proportion of the population risk. METHODS: Using a genomewide linkage scan, we detected linkage between idiopathic interstitial pneumonia and a 3.4-Mb region of chromosome 11p15 in 82 families. We then evaluated genetic variation in this region in gel-forming mucin genes expressed in the lung among 83 subjects with...
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