Exploration of the MUC5B promoter variant and ILD risk in patients with autoimmune myositis.

doi:10.1016/j.rmed.2017.07.010

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Exploration of the MUC5B promoter variant and ILD risk in patients with autoimmune myositis.

Respiratory medicine - 1 Sept 2017

Johnson Cheilonda, Rosen Paul, Lloyd Thomas, Horton Maureen, Christopher-Stine Lisa, Oddis Chester V, Mammen Andrew L, Danoff Sonye K

Abstract excerpt

Interstitial lung disease (ILD) is common in patients with autoimmune myositis but factors that determine susceptibility are unknown. Familial and sporadic idiopathic pulmonary fibrosis (IPF) are strongly associated with a single nucleotide polymorphism in the promoter region of MUC5B (rs35705950). We sought to determine the relationship between MUC5B polymorphism expression and myositis-ILD. The MUC5B minor...

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PMID: 29206633
DOI: 10.1016/j.rmed.2017.07.010

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