Article
Different gene sets contribute to different symptom dimensions of depression and anxiety.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Jul 2012
van Veen Tineke, Goeman Jelle J, Monajemi Ramin, Wardenaar Klaas J, Hartman Catharina A, Snieder Harold, Nolte Ilja M, Penninx Brenda W J H, Zitman Frans G
Abstract excerpt
Although many genetic association studies have been carried out, it remains unclear which genes contribute to depression. This may be due to heterogeneity of the DSM-IV category of depression. Specific symptom-dimensions provide a more homogenous phenotype. Furthermore, as effects of individual genes are small, analysis of genetic data at the pathway-level provides more power to detect associations and yield...
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