Article

Genome-wide analyses of quantitative generalised anxiety symptom severity

2025-07-11

Abstract excerpt

We performed a genome-wide association meta-analysis of generalised anxiety symptom severity in 693,869 individuals of European ancestry from 14 cohorts. We identified 80 independent genome-wide significant variants within 74 loci, 39 of which were novel for anxiety. SNP-based heritability was 5.9% (SE = 0.15%). Polygenic scores were significantly associated with anxiety symptom severity and disorder in European,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8bd4194b-62c8-5357-91f3-d43302f347cd
DOI: 10.1101/2025.07.10.25331321

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genome-wide analyses of quantitative generalised anxiety symptom severityDOI 10.1101/2025.07.10.25331321Read

Genome-wide meta-analysis of quantitatively measured generalized anxiety symptoms in individuals of European ancestry.Semantic proximity Read

Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signalingSemantic proximity Read

Gene discovery and biological insights into anxiety disorders from a large-scale multi-ancestry genome-wide association study.Semantic proximity Read

Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling.Semantic proximity Read

Genome-wide genetic overlap between fear-based disorders and generalised anxiety disorderSemantic proximity Read

Unravelling Sex Differences in the Genetic Architecture of AnxietySemantic proximity Read

Generalised Anxiety Disorder--A Twin Study of Genetic Architecture, Genome-Wide Association and Differential Gene Expression.Semantic proximity Read

Meta-analysis of genome-wide association studies of anxiety disorders.Semantic proximity Read

Genetic contributions to anxiety disorders: where we are and where we are heading.Semantic proximity Read

A Major Role for Common Genetic Variation in Anxiety DisordersSemantic proximity Read

Unravelling sex differences in the genetic architecture of anxiety.Semantic proximity Read

Identification of novel genomic loci for anxiety symptoms and extensive genetic overlap with psychiatric disordersSemantic proximity Read