Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways.

doi:10.1038/s41467-018-03819-3

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways.

Nature communications - 16 Apr 2018

Howard David M, Adams Mark J, Shirali Masoud, Clarke Toni-Kim, Marioni Riccardo E, Davies Gail, Coleman Jonathan R I, Alloza Clara, Shen Xueyi, Barbu Miruna C, Wigmore Eleanor M, Gibson Jude, Hagenaars Saskia P, Lewis Cathryn M, Ward Joey, Smith Daniel J, Sullivan Patrick F, Haley Chris S, Breen Gerome, Deary Ian J, McIntosh Andrew M

Abstract excerpt

Depression is a polygenic trait that causes extensive periods of disability. Previous genetic studies have identified common risk variants which have progressively increased in number with increasing sample sizes of the respective studies. Here, we conduct a genome-wide association study in 322,580 UK Biobank participants for three depression-related phenotypes: broad depression, probable major depressive...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biological Specimen Banks

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Depression

Share to International Classification of Diseases

Share to Major Depressive Disorder

Share to Mechanotransduction, Cellular

Share to Synapses

Share to Synaptic Transmission

Share to United Kingdom

Source

Open in PubMed Open full text

Identifiers

PMID: 29662059
DOI: 10.1038/s41467-018-03819-3
PMCID: PMC5902628

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways.PMID 29662059Read ↗

Genome-wide association study of depression phenotypes in UK Biobank (n = 322,580) identifies the enrichment of variants in excitatory synaptic pathwaysSemantic proximity Read ↗

Addendum: Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways.Semantic proximity Read ↗

Phenomic Network Analysis for Depression Reveals Comorbidity Architecture, Genomic Relationships, and Pleiotropic VariantsSemantic proximity Read ↗

Exome-wide screening identifies novel rare risk variants for major depression disorder.Semantic proximity Read ↗

Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses.Semantic proximity Read ↗

A sex-specific genome-wide association study of depression phenotypes in UK Biobank.Semantic proximity Read ↗

Phenome-wide screening of the putative causal determinants of depression using genetic data.Semantic proximity Read ↗

Whole-exome sequencing in UK Biobank reveals rare genetic architecture for depression.Semantic proximity Read ↗

The Australian Genetics of Depression Study: New Risk Loci and Dissecting Heterogeneity Between Subtypes.Semantic proximity Read ↗

High-throughput sequencing of the synaptome in major depressive disorder.Semantic proximity Read ↗

Whole exome sequencing in the UK Biobank reveals risk gene<i>SLC2A1</i>and biological insights for major depressive disorderSemantic proximity Read ↗

Trans-ancestry genome-wide study of depression identifies 697 associations implicating cell types and pharmacotherapies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.