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Article

Multiple residues in the distal C terminus of the α-subunit have roles in modulating human epithelial sodium channel activity.

American journal of physiology. Renal physiology - 15 Jul 2012

Mueller Gunhild M, Yan Wusheng, Copelovitch Lawrence, Jarman Susan, Wang Zhijian, Kinlough Carol L, Tolino Michael A, Hughey Rebecca P, Kleyman Thomas R, Rubenstein Ronald C

Abstract excerpt

Epithelial sodium channels (ENaC) are critically important in the regulation of ion and fluid balance in both renal and respiratory epithelia. ENaC functional polymorphisms may contribute to alterations in blood pressure in the general population. We previously reported that the A663T polymorphism in the C terminus of the α-subunit altered ENaC functional and surface expression in Xenopus laevis oocytes (Samaha...

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Identifiers

PMID: 22573385
DOI: 10.1152/ajprenal.00493.2011
PMCID: PMC3404586

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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