Article
Human epithelial Na+ channel missense variants identified in the GenSalt study alter channel activity.
American journal of physiology. Renal physiology - 1 Nov 2016
Ray Evan C, Chen Jingxin, Kelly Tanika N, He Jiang, Hamm L Lee, Gu Dongfeng, Shimmin Lawrence C, Hixson James E, Rao Dabeeru C, Sheng Shaohu, Kleyman Thomas R
Abstract excerpt
Mutations in genes encoding subunits of the epithelial Na+ channel (ENaC) can cause early onset familial hypertension, demonstrating the importance of this channel in modulating blood pressure. It remains unclear whether other genetic variants resulting in subtler alterations of channel function result in hypertension or altered sensitivity of blood pressure to dietary salt. This study sought to identify...
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