Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic variation of the alpha subunit of the epithelial Na+ channel influences exhaled Na+ in healthy humans.

Respiratory physiology & neurobiology - 15 Dec 2011

Foxx-Lupo William T, Wheatley Courtney M, Baker Sarah E, Cassuto Nicholas A, Delamere Nicholas A, Snyder Eric M

Abstract excerpt

Epithelial Na(+) channels (ENaC) are located in alveolar cells and are important in β(2)-adrenergic receptor-mediated lung fluid clearance through the removal of Na(+) from the alveolar airspace. Previous work has demonstrated that genetic variation of the alpha subunit of ENaC at amino acid 663 is important in channel function: cells with the genotype resulting in alanine at amino acid 663 (A663) demonstrate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epithelial Sodium Channels
Share to Exhalation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genotype

Share to Polymorphism, Single Nucleotide

Share to Real-Time Polymerase Chain Reaction

Share to Respiratory Function Tests

Share to Sodium

Share to Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 21889619
DOI: 10.1016/j.resp.2011.08.008
PMCID: PMC3215916

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variation of the alpha subunit of the epithelial Na+ channel influences exhaled Na+ in healthy humans.PMID 21889619Read ↗

Genetic variation of αENaC influences lung diffusion during exercise in humans.Semantic proximity Read ↗

Genetic variation of SCNN1A influences lung diffusing capacity in cystic fibrosis.Semantic proximity Read ↗

Multiple residues in the distal C terminus of the α-subunit have roles in modulating human epithelial sodium channel activity.Semantic proximity Read ↗

Human epithelial Na+ channel missense variants identified in the GenSalt study alter channel activity.Semantic proximity Read ↗

Functional polymorphism in the carboxyl terminus of the alpha-subunit of the human epithelial sodium channel.Semantic proximity Read ↗

Genetic disorders of membrane transport. V. The epithelial sodium channel and its implication in human diseases.Semantic proximity Read ↗

beta-Liddle mutation of the epithelial sodium channel increases alveolar fluid clearance and reduces the severity of hydrostatic pulmonary oedema in mice.Semantic proximity Read ↗

Blood pressure variation in healthy humans: a possible interaction with beta-2 adrenergic receptor genotype and renal epithelial sodium channels.Semantic proximity Read ↗

Influence of genetic variation of the β2-adrenergic receptor on lung diffusion in patients with cystic fibrosis.Semantic proximity Read ↗

T594M variant of the epithelial sodium channel beta-subunit gene and hypertension in individuals of African ancestry in South Africa.Semantic proximity Read ↗

A novel variant of the beta-subunit of the amiloride-sensitive sodium channel in African Americans.Semantic proximity Read ↗

Genetic variation in the epithelial sodium channel: a risk factor for hypertension in people of African origin.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.