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Article

Functional polymorphism in the carboxyl terminus of the alpha-subunit of the human epithelial sodium channel.

The Journal of biological chemistry - 4 Jun 2004

Samaha Frederick F, Rubenstein Ronald C, Yan Wusheng, Ramkumar Mohan, Levy Daniel I, Ahn Yoon J, Sheng Shaohu, Kleyman Thomas R

Abstract excerpt

A common human epithelial sodium channel (ENaC) polymorphism, alphaT663A, is present in the cytoplasmic C terminus of the alpha-subunit, although it is unclear whether this polymorphism segregates with blood pressure. We examined whether this polymorphism was associated with differences in functional Na(+) channel expression. Whole cell amiloride-sensitive currents in Xenopus oocytes expressing wild type channels...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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PMID: 15069064
DOI: 10.1074/jbc.M401941200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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