Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polymorphisms in the carboxy-terminus of the epithelial sodium channel in rat models for hypertension.

Journal of hypertension - 1 Feb 1997

Gründer S, Zagato L, Yagil C, Yagil Y, Sassard J, Rossier B C

Abstract excerpt

OBJECTIVE: To investigate whether mutations in the C-terminus of the three subunits of the rat epithelial sodium channel (alphabetagamma-rENaC) contribute to the hypertensive phenotype in five rat models for essential hypertension. DESIGN: We sequenced the C-terminal regions of alpha-, beta- and gamma-rENaC genes in five different hypertensive rat strains [spontaneously hypertensive rats (SHR), Dahl...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epithelium
Share to Hypertension
Share to Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Polymorphism, Genetic

Share to Rats, Inbred SHR

Share to Rats, Inbred WKY

Share to Sodium Channels

Source

Identifiers

PMID: 9469793
DOI: 10.1097/00004872-199715020-00008

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polymorphisms in the carboxy-terminus of the epithelial sodium channel in rat models for hypertension.PMID 9469793Read ↗

Mutations in the carboxy terminus of the beta and gamma subunits of the epithelial sodium channel are not present in patients with hypertensive crisis.Semantic proximity Read ↗

Polymorphisms of the gamma subunit of the epithelial Na+ channel in essential hypertension.Semantic proximity Read ↗

Genotype-phenotype analysis of a newly discovered family with Liddle's syndrome.Semantic proximity Read ↗

Functional polymorphism in the carboxyl terminus of the alpha-subunit of the human epithelial sodium channel.Semantic proximity Read ↗

Japanese individuals do not harbor the T594M mutation but do have the P592S mutation in the C-terminus of the beta-subunit of the epithelial sodium channel: the Ohasama study.Semantic proximity Read ↗

Hypertension caused by a truncated epithelial sodium channel gamma subunit: genetic heterogeneity of Liddle syndrome.Semantic proximity Read ↗

A de novo missense mutation of the beta subunit of the epithelial sodium channel causes hypertension and Liddle syndrome, identifying a proline-rich segment critical for regulation of channel activity.Semantic proximity Read ↗

Common variants of the beta and gamma subunits of the epithelial sodium channel and their relation to plasma renin and aldosterone levels in essential hypertension.Semantic proximity Read ↗

Role of the alpha-, beta-, and gamma-subunits of epithelial sodium channel in a model of polygenic hypertension.Semantic proximity Read ↗

Multiple residues in the distal C terminus of the α-subunit have roles in modulating human epithelial sodium channel activity.Semantic proximity Read ↗

Mutations and variants of the epithelial sodium channel gene in Liddle's syndrome and primary hypertension.Semantic proximity Read ↗

Genetic variation of the gamma subunit of the epithelial Na+ channel and essential hypertension. Relationship with salt sensitivity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.