Article
A novel variant of the beta-subunit of the amiloride-sensitive sodium channel in African Americans.
Journal of the American Society of Nephrology : JASN - 1 Dec 1996
Su Y R, Rutkowski M P, Klanke C A, Wu X, Cui Y, Pun R Y, Carter V, Reif M, Menon A G
Abstract excerpt
The amiloride-sensitive sodium channel is responsible for the rate-limiting step of sodium reabsorption in the distal renal tubule, and thus may play a key role in the maintenance of sodium balance and blood pressure. In this study, a genetic variant that results in a change of threonine to methi...
Topics
- Aldosterone
- Amiloride
- Amino Acid Sequence
- B-Lymphocytes
- Base Sequence
- Black People
- Blood Pressure
- Codon
- DNA
- Diuretics
- Electric Conductivity
- Epithelial Sodium Channels
- Genetic Variation
- Humans
- In Vitro Techniques
- Membrane Potentials
- Natriuresis
- Sodium Channels