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Article

Prediction of the impact of coding missense and nonsense single nucleotide polymorphisms on HD5 and HBD1 antibacterial activity against Escherichia coli.

Biopolymers - 1 Sept 2016

Porto William F, Nolasco Diego O, Pires Állan S, Pereira Rinaldo W, Franco Octávio L, Alencar Sérgio A

Abstract excerpt

Defensins confer host defense against microorganisms and are important for human health. Single nucleotide polymorphisms (SNPs) in defensin gene-coding regions could lead to less active variants. Using SNP data available at the dbSNP database and frequency information from the 1000 Genomes Project, two DEFA5 (L26I and R13H) and eight DEFB1 (C35S, K31T, K33R, R29G, V06I, C12Y, Y28* and C05*) missense and nonsense...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27160989
DOI: 10.1002/bip.22866

Genes

DEFA5
DEFB1

Variants

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