Article
Novel Genetic Variants for Cartilage Thickness and Hip Osteoarthritis.
PLoS genetics - 1 Oct 2016
Castaño-Betancourt Martha C, Evans Dan S, Ramos Yolande F M, Boer Cindy G, Metrustry Sarah, Liu Youfang, den Hollander Wouter, van Rooij Jeroen, Kraus Virginia B, Yau Michelle S, Mitchell Braxton D, Muir Kenneth, Hofman Albert, Doherty Michael, Doherty Sally, Zhang Weiya, Kraaij Robert, Rivadeneira Fernando, Barrett-Connor Elizabeth, Maciewicz Rose A, Arden Nigel, Nelissen Rob G H H, Kloppenburg Margreet, Jordan Joanne M, Nevitt Michael C, Slagboom Eline P, Hart Deborah J, Lafeber Floris, Styrkarsdottir Unnur, Zeggini Eleftheria, Evangelou Evangelos, Spector Tim D, Uitterlinden Andre G, Lane Nancy E, Meulenbelt Ingrid, Valdes Ana M, van Meurs Joyce B J
Abstract excerpt
Osteoarthritis is one of the most frequent and disabling diseases of the elderly. Only few genetic variants have been identified for osteoarthritis, which is partly due to large phenotype heterogeneity. To reduce heterogeneity, we here examined cartilage thickness, one of the structural components of joint health. We conducted a genome-wide association study of minimal joint space width (mJSW), a proxy for...
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