Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Soluble immune complexes shift the TLR-induced cytokine production of distinct polarized human macrophage subsets towards IL-10.

PloS one - 1 Jan 2012

Ambarus Carmen A, Santegoets Kim C M, van Bon Lenny, Wenink Mark H, Tak Paul P, Radstake Timothy R D J, Baeten Dominique L P

Abstract excerpt

BACKGROUND: Costimulation of murine macrophages with immune complexes (ICs) and TLR ligands leads to alternative activation. Studies on human myeloid cells, however, indicate that ICs induce an increased pro-inflammatory cytokine production. This study aimed to clarify the effect of ICs on the pro- versus anti-inflammatory profile of human polarized macrophages. MATERIALS AND METHODS: Monocytes isolated from...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigen-Antibody Complex
Share to Immunoglobulin G

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interleukin-10

Share to Interleukin-23

Share to Ligands

Share to Lipopolysaccharides

Share to Macrophages

Share to Toll-Like Receptors

Source

Open in PubMed Open full text

Identifiers

PMID: 22563430
DOI: 10.1371/journal.pone.0035994
PMCID: PMC3338562

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Soluble immune complexes shift the TLR-induced cytokine production of distinct polarized human macrophage subsets towards IL-10.PMID 22563430Read ↗

Systematic validation of specific phenotypic markers for in vitro polarized human macrophages.Semantic proximity Read ↗

IFN-γ Drives Human Monocyte Differentiation into Highly Proinflammatory Macrophages That Resemble a Phenotype Relevant to Psoriasis.Semantic proximity Read ↗

An optimized protocol for human M2 macrophages using M-CSF and IL-4/IL-10/TGF-β yields a dominant immunosuppressive phenotype.Semantic proximity Read ↗

Differential gene expression in human, murine, and cell line-derived macrophages upon polarization.Semantic proximity Read ↗

Phenotypic and functional profiling of human proinflammatory type-1 and anti-inflammatory type-2 macrophages in response to microbial antigens and IFN-gamma- and CD40L-mediated costimulation.Semantic proximity Read ↗

Profiling of Macrophage Polarization Using Automated Enzyme-Linked Immunosorbent Assay.Semantic proximity Read ↗

IL-34 induces the differentiation of human monocytes into immunosuppressive macrophages. antagonistic effects of GM-CSF and IFNγ.Semantic proximity Read ↗

Intimal lining layer macrophages but not synovial sublining macrophages display an IL-10 polarized-like phenotype in chronic synovitis.Semantic proximity Read ↗

Temporal phenotypic features distinguish polarized macrophages in vitro.Semantic proximity Read ↗

Primary human macrophages are polarized towards pro-inflammatory phenotypes in alginate hydrogelsSemantic proximity Read ↗

Reversible differentiation of pro- and anti-inflammatory macrophages.Semantic proximity Read ↗

CD5L Promotes M2 Macrophage Polarization through Autophagy-Mediated Upregulation of ID3.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.