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Article

CD5L Promotes M2 Macrophage Polarization through Autophagy-Mediated Upregulation of ID3.

Frontiers in immunology - 1 Jan 2018

Sanjurjo Lucía, Aran Gemma, Téllez Érica, Amézaga Núria, Armengol Carolina, López Daniel, Prats Clara, Sarrias Maria-Rosa

Abstract excerpt

CD5L (CD5 molecule-like) is a secreted glycoprotein that controls key mechanisms in inflammatory responses, with involvement in processes such as infection, atherosclerosis, and cancer. In macrophages, CD5L promotes an anti-inflammatory cytokine profile in response to TLR activation. In the present study, we questioned whether CD5L is able to influence human macrophage plasticity, and drive its polarization...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29593730
DOI: 10.3389/fimmu.2018.00480
PMCID: PMC5858086

Genes

ATG7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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