Article
Intimal lining layer macrophages but not synovial sublining macrophages display an IL-10 polarized-like phenotype in chronic synovitis.
Arthritis research & therapy - 11 Apr 2012
Ambarus Carmen A, Noordenbos Troy, de Hair Maria J H, Tak Paul P, Baeten Dominique L P
Abstract excerpt
INTRODUCTION: Synovial tissue macrophages play a key role in chronic inflammatory arthritis, but the contribution of different macrophage subsets in this process remains largely unknown. The main in vitro polarized macrophage subsets are classically (M1) and alternatively (M2) activated macrophages, the latter comprising interleukin (IL)-4 and IL-10 polarized cells. Here, we aimed to evaluate the polarization...
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