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Article

Disruption of the Human SCL Locus by "Illegitimate" V-(D)-J Recombinase Activity

7 Dec 1990

Abstract excerpt

A fusion complementary DNA in the T cell line HSB-2 elucidates a provocative mechanism for the disruption of the putative hematopoietic transcription factor SCL. The fusion cDNA results from an interstitial deletion between a previously unknown locus, SIL (SCL interrupting locus), and the 5' untranslated region of SCL. Similar to 1;14 translocations, this deletion disrupts the SCL 5' regulatory region. This event...

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Identifiers

PMID: 2255914
DOI: 10.1126/science.2255914

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Disruption of the Human SCL Locus by "Illegitimate" V-(D)-J Recombinase ActivityPMID 2255914Read ↗

The SCL Gene Is Formed from a Transcriptionally Complex LocusSemantic proximity Read ↗

Involvement of the putative hematopoietic transcription factor SCL in T-cell acute lymphoblastic leukemia.Semantic proximity Read ↗

Structural characterization of SIL, a gene frequently disrupted in T-cell acute lymphoblastic leukemia.Semantic proximity Read ↗

An scl gene product lacking the transactivation domain induces bony abnormalities and cooperates with LMO1 to generate T-cell malignancies in transgenic mice.Semantic proximity Read ↗

Long-range comparison of human and mouse SCL loci: localized regions of sensitivity to restriction endonucleases correspond precisely with peaks of conserved noncoding sequences.Semantic proximity Read ↗

Transcriptional Regulation of the SCL Locus: Identification of an Enhancer That Targets the Primitive Erythroid Lineage In VivoSemantic proximity Read ↗

Rescue of the lethal scl(-/-) phenotype by the human SCL locus.Semantic proximity Read ↗

Adult hematopoietic stem and progenitor cells require either Lyl1 or Scl for survival.Semantic proximity Read ↗

Molecular cloning and chromosomal localization of the murine homolog of the human helix-loop-helix gene SCL.Semantic proximity Read ↗

Analysis of the V(D)J Recombination Efficiency at Lymphoid Chromosomal Translocation BreakpointsSemantic proximity Read ↗

Differential use of SCL/TAL-1 DNA-binding domain in developmental hematopoiesisSemantic proximity Read ↗

The paralogous hematopoietic regulators Lyl1 and Scl are coregulated by Ets and GATA factors, but Lyl1 cannot rescue the early Scl-/- phenotype.Semantic proximity Read ↗

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