Article
Molecular cloning and chromosomal localization of the murine homolog of the human helix-loop-helix gene SCL.
Proceedings of the National Academy of Sciences of the United States of America - 1 Feb 1991
Begley C G, Visvader J, Green A R, Aplan P D, Metcalf D, Kirsch I R, Gough N M
Abstract excerpt
The human SCL gene is a member of the family of genes that encode the helix-loop-helix (HLH) class of DNA-binding proteins. A murine SCL cDNA was isolated from a normal macrophage cDNA library by using HLH-specific oligonucleotides as hybridization probes. The coding region is 987 base pairs and encodes a predicted protein of 34 kDa. The nucleotide sequence of the coding region shows 88% identity to the human SCL...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Base Sequence
- Basic Helix-Loop-Helix Transcription Factors
- Blotting, Northern
- Blotting, Southern
- Chromosome Mapping
- Cloning, Molecular
- DNA-Binding Proteins