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Article

Structural characterization of SIL, a gene frequently disrupted in T-cell acute lymphoblastic leukemia.

1 Nov 1991

Abstract excerpt

The SIL (SCL interrupting locus) gene was initially discovered at the site of a genomic rearrangement in a T-cell acute lymphoblastic leukemia cell line. This rearrangement, which occurs in a remarkably site-specific fashion, is present in the leukemic cells of 16 to 26% of patients with T-cell acute lymphoblastic leukemia. We have now cloned a normal SIL cDNA from a cell line which does not carry the...

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Identifiers

PMID: 1922059
DOI: 10.1128/mcb.11.11.5462

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