Article
Involvement of the putative hematopoietic transcription factor SCL in T-cell acute lymphoblastic leukemia.
Blood - 1 Mar 1992
Aplan P D, Lombardi D P, Reaman G H, Sather H N, Hammond G D, Kirsch I R
Abstract excerpt
The SCL gene, initially discovered at the site of a translocation breakpoint associated with the development of a stem cell leukemia, encodes a protein that contains the highly conserved basic helix-loop-helix (bHLH) motif found in a large array of eukaryotic transcription factors. Recently, we h...
Topics
- Alleles
- Base Sequence
- Basic Helix-Loop-Helix Transcription Factors
- Blotting, Southern
- Child
- DNA, Neoplasm
- DNA-Binding Proteins
- Gene Expression Regulation, Neoplastic
- Gene Rearrangement
- Gene Rearrangement, delta-Chain T-Cell Antigen Receptor
- Humans
- Immunophenotyping
- Leukemia-Lymphoma, Adult T-Cell
- Molecular Sequence Data
- Promoter Regions, Genetic
- Proto-Oncogene Proteins
- RNA, Messenger
- T-Cell Acute Lymphocytic Leukemia Protein 1