Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Involvement of the putative hematopoietic transcription factor SCL in T-cell acute lymphoblastic leukemia.

Blood - 1 Mar 1992

Aplan P D, Lombardi D P, Reaman G H, Sather H N, Hammond G D, Kirsch I R

Abstract excerpt

The SCL gene, initially discovered at the site of a translocation breakpoint associated with the development of a stem cell leukemia, encodes a protein that contains the highly conserved basic helix-loop-helix (bHLH) motif found in a large array of eukaryotic transcription factors. Recently, we have described a nonrandom, site-specific SCL rearrangement in several T-cell acute lymphoblastic leukemia (ALL) cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Base Sequence
Share to Blotting, Southern

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA-Binding Proteins

Share to Molecular Sequence Data

Share to Promoter Regions, Genetic

Share to RNA, Messenger

Source

Identifiers

PMID: 1311214

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Involvement of the putative hematopoietic transcription factor SCL in T-cell acute lymphoblastic leukemia.PMID 1311214Read ↗

Structural characterization of SIL, a gene frequently disrupted in T-cell acute lymphoblastic leukemia.Semantic proximity Read ↗

Disruption of the Human SCL Locus by "Illegitimate" V-(D)-J Recombinase ActivitySemantic proximity Read ↗

The SCL Gene Is Formed from a Transcriptionally Complex LocusSemantic proximity Read ↗

Transcriptional Regulation of the SCL Locus: Identification of an Enhancer That Targets the Primitive Erythroid Lineage In VivoSemantic proximity Read ↗

An scl gene product lacking the transactivation domain induces bony abnormalities and cooperates with LMO1 to generate T-cell malignancies in transgenic mice.Semantic proximity Read ↗

Transcriptional regulatory networks downstream of TAL1/SCL in T-cell acute lymphoblastic leukemiaSemantic proximity Read ↗

Long-range comparison of human and mouse SCL loci: localized regions of sensitivity to restriction endonucleases correspond precisely with peaks of conserved noncoding sequences.Semantic proximity Read ↗

The paralogous hematopoietic regulators Lyl1 and Scl are coregulated by Ets and GATA factors, but Lyl1 cannot rescue the early Scl-/- phenotype.Semantic proximity Read ↗

Adult hematopoietic stem and progenitor cells require either Lyl1 or Scl for survival.Semantic proximity Read ↗

Rescue of the lethal scl(-/-) phenotype by the human SCL locus.Semantic proximity Read ↗

Differential use of SCL/TAL-1 DNA-binding domain in developmental hematopoiesisSemantic proximity Read ↗

Specification of hematopoietic and vascular development by the bHLH transcription factor SCL without direct DNA binding.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.