Article
PET evidence of preclinical cerebellar amyloid plaque deposition in autosomal dominant Alzheimer's disease-causing Presenilin-1 E280A mutation carriers.
NeuroImage. Clinical - 1 Jan 2021
Ghisays Valentina, Lopera Francisco, Goradia Dhruman D, Protas Hillary D, Malek-Ahmadi Michael H, Chen Yinghua, Devadas Vivek, Luo Ji, Lee Wendy, Baena Ana, Bocanegra Yamile, Guzmán-Vélez Edmarie, Pardilla-Delgado Enmanuelle, Vila-Castelar Clara, Fox-Fuller Joshua T, Hu Nan, Clayton David, Thomas Ronald G, Alvarez Sergio, Espinosa Alejandro, Acosta-Baena Natalia, Giraldo Margarita M, Rios-Romenets Silvia, Langbaum Jessica B, Chen Kewei, Su Yi, Tariot Pierre N, Quiroz Yakeel T, Reiman Eric M
Abstract excerpt
BACKGROUND: In contrast to sporadic Alzheimer's disease, autosomal dominant Alzheimer's disease (ADAD) is associated with greater neuropathological evidence of cerebellar amyloid plaque (Aβ) deposition. In this study, we used positron emission tomography (PET) measurements of fibrillar Aβ burden to characterize the presence and age at onset of cerebellar Aβ deposition in cognitively unimpaired (CU) Presenilin-1...
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