Article
Association of heat shock proteins with all-cause mortality.
Age (Dordrecht, Netherlands) - 1 Aug 2013
Broer L, Demerath E W, Garcia M E, Homuth G, Kaplan R C, Lunetta K L, Tanaka T, Tranah G J, Walter S, Arnold A M, Atzmon G, Harris T B, Hoffmann W, Karasik D, Kiel D P, Kocher T, Launer L J, Lohman K K, Rotter J I, Tiemeier H, Uitterlinden A G, Wallaschofski H, Bandinelli S, Dörr M, Ferrucci L, Franceschini N, Gudnason V, Hofman A, Liu Y, Murabito J M, Newman A B, Oostra B A, Psaty B M, Smith A V, van Duijn C M
Abstract excerpt
Experimental mild heat shock is widely known as an intervention that results in extended longevity in various models along the evolutionary lineage. Heat shock proteins (HSPs) are highly upregulated immediately after a heat shock. The elevation in HSP levels was shown to inhibit stress-mediated cell death, and recent experiments indicate a highly versatile role for these proteins as inhibitors of programmed cell...
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