Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic determinants of HSP70 gene expression following heat shock.

Human molecular genetics - 15 Dec 2010

Maugeri Narelle, Radhakrishnan Jayachandran, Knight Julian C

Abstract excerpt

The regulation of heat shock protein expression is of significant physiological and pathophysiological significance. Here we show that genetic diversity is an important determinant of heat shock protein 70 expression involving local, likely cis-acting, polymorphisms. We define DNA sequence variation for the highly homologous HSPA1A and HSPA1B genes in the major histocompatibility complex on chromosome 6p21 and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Cell Line
Share to Gene Expression Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Variation

Share to Heat-Shock Response

Share to HSP70 Heat-Shock Proteins

Share to Polymorphism, Single Nucleotide

Share to Quantitative Trait Loci

Source

Open in PubMed Open full text

Identifiers

PMID: 20876613
DOI: 10.1093/hmg/ddq418
PMCID: PMC2989893

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic determinants of HSP70 gene expression following heat shock.PMID 20876613Read ↗

Characterisation of the global transcriptional response to heat shock and the impact of individual genetic variation.Semantic proximity Read ↗

Cellular thermotolerance is associated with heat shock protein 70.1 genetic polymorphisms in Holstein lactating cows.Semantic proximity Read ↗

Concurrent action of purifying selection and gene conversion results in extreme conservation of the major stress-inducible Hsp70 genes in mammals.Semantic proximity Read ↗

Variation in hsp gene expression and Hsp polymorphism: do they contribute to differential disease susceptibility and stress tolerance?Semantic proximity Read ↗

The human heat-shock protein family. Expression of a novel heat-inducible HSP70 (HSP70B′) and isolation of its cDNA and genomic DNASemantic proximity Read ↗

Genetic variation in heat shock protein 70 is associated with septic shock: narrowing the association to a specific haplotype.Semantic proximity Read ↗

Next Generation Sequencing of Genotype Variants and Genetic Association between Heat Shock Proteins HSPA1B Single Nucleotide Polymorphism at the g.31829044 Locus and Heat Tolerance: A Pilot Quasi-Experimental Study.Semantic proximity Read ↗

Polymorphism in the regulatory sequence of the human hsp70-1 gene does not affect heat shock factor binding or heat shock protein synthesis.Semantic proximity Read ↗

HLA complex-linked heat shock protein genes and childhood acute lymphoblastic leukemia susceptibility.Semantic proximity Read ↗

Novel polymorphisms in UTR and coding region of inducible heat shock protein 70.1 gene in tropically adapted Indian zebu cattle (Bos indicus) and riverine buffalo (Bubalus bubalis).Semantic proximity Read ↗

Comparative analysis of differential gene expression of HSP40 and HSP70 family isoforms during heat stress and HIV-1 infection in T-cellsSemantic proximity Read ↗

Association of heat shock proteins with all-cause mortality.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.