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Article

An age-dependent reversal in the protective capacities of JNK signaling shortens Caenorhabditis elegans lifespan.

Aging cell - 1 Aug 2012

Twumasi-Boateng Kwame, Wang Tim W, Tsai Linda, Lee Kuang-Hui, Salehpour Ali, Bhat Sudarshan, Tan Man-Wah, Shapira Michael

Abstract excerpt

Stress-activated protein kinase (SAPK) pathways are evolutionarily conserved signaling modules that orchestrate protective responses to adverse environmental conditions. However, under certain conditions, their activation can be deleterious. Thus, activation of the c-Jun N-terminal kinase (JNK) SAPK pathway exacerbates a diverse set of pathologies, many of which are typical of old age. The contexts determining...

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Identifiers

PMID: 22554143
DOI: 10.1111/j.1474-9726.2012.00829.x
PMCID: PMC3440580

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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