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Article

JNK signaling confers tolerance to oxidative stress and extends lifespan in Drosophila.

Developmental cell - 1 Nov 2003

Wang Meng C, Bohmann Dirk, Jasper Heinrich

Abstract excerpt

Changes in the genetic makeup of an organism can extend lifespan significantly if they promote tolerance to environmental insults and thus prevent the general deterioration of cellular function that is associated with aging. Here, we introduce the Jun N-terminal kinase (JNK) signaling pathway as a genetic determinant of aging in Drosophila melanogaster. Based on expression profiling experiments, we demonstrate...

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PMID: 14602080
DOI: 10.1016/s1534-5807(03)00323-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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