Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Increased age reduces DAF-16 and SKN-1 signaling and the hormetic response of Caenorhabditis elegans to the xenobiotic juglone.

Mechanisms of ageing and development - 1 Jun 2009

Przybysz Aaron J, Choe Keith P, Roberts L Jackson, Strange Kevin

Abstract excerpt

Cells adapt to stressors by activating mechanisms that repair damage and protect them from further injury. Stress-induced damage accumulates with age and contributes to age associated diseases. Increased age attenuates the ability to mount a stress response, but little is known about the mechanisms by which this occurs. To begin addressing this problem, we studied hormesis in the nematode Caenorhabditis elegans....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caenorhabditis elegans
Share to Caenorhabditis elegans Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytoprotection

Share to Down-Regulation

Share to Forkhead Transcription Factors

Share to Naphthoquinones

Share to Transcriptional Activation

Share to Xenobiotics

Source

Open in PubMed Open full text

Identifiers

PMID: 19428455
DOI: 10.1016/j.mad.2009.02.004
PMCID: PMC2680786

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Increased age reduces DAF-16 and SKN-1 signaling and the hormetic response of Caenorhabditis elegans to the xenobiotic juglone.PMID 19428455Read ↗

An age-dependent reversal in the protective capacities of JNK signaling shortens Caenorhabditis elegans lifespan.Semantic proximity Read ↗

Methyl 3,4-Dihydroxybenzoate Enhances Resistance to Oxidative Stressors and Lifespan in C. elegans Partially via daf-2/daf-16.Semantic proximity Read ↗

DAF-16/FOXO maintains genome integrity following genotoxic stressSemantic proximity Read ↗

Gastrodin extends the lifespan of Caenorhabditis elegans via the DAF-16/FOXO signaling pathway and autophagySemantic proximity Read ↗

Host cell factor 1 inhibits SKN-1 to modulate oxidative stress responses in Caenorhabditis elegans.Semantic proximity Read ↗

Longevity genes in the nematode Caenorhabditis elegans also mediate increased resistance to stress and prevent disease.Semantic proximity Read ↗

Hypoxia-reoxygenation Extends the Lifespan of Caenorhabditis elegans via SKN-1- and DAF-16A-Dependent Stress HormesisSemantic proximity Read ↗

Abalone peptide increases stress resilience and cost‐free longevity via SKN ‐1‐governed transcriptional metabolic reprogramming in C. elegansSemantic proximity Read ↗

Caenorhabditis elegans DAF-16/FOXO transcription factor and its mammalian homologs associate with age-related diseaseSemantic proximity Read ↗

Hormesis in Caenorhabditis elegans dauer-defective mutants.Semantic proximity Read ↗

Inhibition of the neuromuscular acetylcholine receptor with atracurium activates FOXO/DAF-16-induced longevitySemantic proximity Read ↗

Extension of lifespan in C. elegans by naphthoquinones that act through stress hormesis mechanisms.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.