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Article

Polymorphisms in the TLR3 gene are associated with risk for type 1 diabetes mellitus.

European journal of endocrinology - 1 Apr 2014

Assmann Taís Silveira, Brondani Letícia de Almeida, Bauer Andrea Carla, Canani Luis Henrique, Crispim Daisy

Abstract excerpt

INTRODUCTION: Viral pathogens seem to play a role in triggering the autoimmune destruction that leads to the development of type 1 diabetes mellitus (T1DM). Toll-like receptor 3 (TLR3) has been shown to recognize double-stranded RNA, a molecular signature of most viruses. It is expressed at high levels in pancreatic β-cells and immune cells, suggesting a role for it in the pathogenesis of T1DM. Therefore, the aim...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24408902
DOI: 10.1530/EJE-13-0963

Genes

TLR3

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