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Article

Association of TLR3-hyporesponsiveness and functional TLR3 L412F polymorphism with recurrent herpes labialis.

Human immunology - 1 Aug 2012

Yang Chin-An, Raftery Martin J, Hamann Lutz, Guerreiro Manuel, Grütz Gerald, Haase Doreen, Unterwalder Nadine, Schönrich Günther, Schumann Ralf R, Volk Hans-Dieter, Scheibenbogen Carmen

Abstract excerpt

HSV-1 persistently infects almost 90% of our population; however, only 30% of the infected subjects suffer from recurrent herpes lesions, most frequently herpes labialis (HL). We hypothesized that variations in toll-like receptor (TLR) functions might contribute to HL susceptibility. In our study, the TLR-2/1,-3, and -7/8 responses of immune cell subsets derived from asymptomatic HSV-1 carriers were compared with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22537752
DOI: 10.1016/j.humimm.2012.04.008

Genes

TLR3

Variants

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