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Article

A real-time PCR assay for the simultaneous detection of functional N284I and L412F polymorphisms in the human Toll-like receptor 3 gene.

The Journal of molecular diagnostics : JMD - 1 Jul 2010

Brown Robert A, Razonable Raymund R

Abstract excerpt

Toll-like receptors (TLR) serve important roles in immunity against microbial pathogens, and TLR3 plays a critical role in the recognition of double-stranded RNA derived from viruses. Two specific single nucleotide polymorphisms (SNP) in the human TLR3 gene, A851T and C1234T, which result in amino acid substitutions, N284I and L412F, respectively, have been described to result in impaired receptor signaling and...

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Identifiers

PMID: 20413676
DOI: 10.2353/jmoldx.2010.090122
PMCID: PMC2893634

Genes

TLR3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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