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Article

Modification of interface between regulatory and essential light chains hampers phosphorylation-dependent activation of smooth muscle myosin.

The Journal of biological chemistry - 22 Jun 2012

Ni Shaowei, Hong Feng, Haldeman Brian D, Baker Josh E, Facemyer Kevin C, Cremo Christine R

Abstract excerpt

We examined the regulatory importance of interactions between regulatory light chain (RLC), essential light chain (ELC), and adjacent heavy chain (HC) in the regulatory domain of smooth muscle heavy meromyosin. After mutating the HC, RLC, and/or ELC to disrupt their predicted interactions (using scallop myosin coordinates), we measured basal ATPase, V(max), and K(ATPase) of actin-activated ATPase, actin-sliding...

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Identifiers

PMID: 22549781
DOI: 10.1074/jbc.M112.343491
PMCID: PMC3381165

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Source receipt: pubmed, retrieved 7 Sept 2026.

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